Faculty Profile - Joseph A. Knezetic, Ph.D.

Joseph A. Knezetic, Ph.D.
Director, Laboratory of Molecular Pathology and Diagnostics

Creighton Medical Laboratories
Creighton University
Department of Pathology
2500 California Plaza
Omaha, NE 68178
(402) 280-2511
joek@creighton.edu
  • Associate Professor of Pathology

Education

  • B.S. - Bowling Green State University, Bowling Green, Ohio (1981)
  • Ph.D. - University of Cincinnati, Cincinnati, Ohio (1986)
  • Fellow, National Institutes of Health, Bethesda, Maryland (1986)

Publications

  • Knezetic JA, Luse DS. The presence of nucleosomes on a DNA template prevents initiation by RNA polymerase II in vitro. Cell 1986;45:95-104.
  • Knezetic JA, Jacob GA, Luse DS. Assembly of RNA polymerase II preinitiation complexes before assembly of nucleosomes allows efficient initiation of transcription on nucleosomal templates. Molecular and Cellular Biology 1988;8:3114-3121.
  • Felsenfeld G, Clark D, Clark S, Evans T, Gibney G, Jackson PD, Knezetic J, Lewis C, Minnie M, Reitmen M, Trainor C. Developmental regulation of chicken globin gene expression. In: Styamatoyannopoulos G, Nienhuis AW, editors. Hemoglobin Switching. New York: Alan R. Liss, 1991, pp. 237-248.
  • Knezetic JA, Felsenfeld G. Mechanism of developmental regulation of , the chicken embryonic -globin gene. Molecular and Cellular Biology 1993;13:4632-4639.
  • Wang Q, Knezetic JA, Schally AV, Pour PM, Adrian TE. Bombesis may stimulate proliferation of human pancreatic cancer cells through an autocrine pathway. Int J Cancer 1996;68:528-534.
  • Kinyamu HK, Gallagher JC, Knezetic JA, Deluca HF, Prahl JM, Lanspa SJ. Effect of vitamin D receptor genotypes on calcium absorption, duodenal vitamin D receptor concentration and serum 1,25 hydroxyvitamin D levels in normal women. Calcified Tissue Int 1997;60:491-495.
  • Thorson AG, Knezetic JA, Lynch H. A century of progress in hereditary nonpolyposis colorectal cancer (Lynch syndrome). Dis Colon Rectum1999;42:1-9.
  • Ichikawa Y, Lemon SJ, Wang S, Franklin B, Knezetic JA, Bewtra C, Lynch HT. Microsatellite instability and expression of MLH1 and MLH2 in normal and malignant endometrial and ovarian epithelium in hereditary nonpolyposis colorectal cancer family members. Cancer Genet Cytogenet 1999;112:2-8.
  • Ding X, Iverson P, El-Metwaley TH, Cluck MW, Knezetic JA, Adrian TE. Lipooxygenase inhibitors abolish proliferation of human pancreatic cancer cells. Biochem Biophys Res Commun 1999;261:218-223.
  • Liu J, Knezetic JA, Strommer L, Permert J, Larsson J, Adrian TE. The intracellular mechanism of insulin resistance in pancreatic cancer patients. J Clin Endocrinol Metab 2000;85:1232-1238.
  • Murphy LO, Cluck MW, Lovas S, Otvos F, Murphy AV, Schally J, Permert J, Larsson J, Knezetic JA, Adrian TE. Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions. Br J Cancer 2001;84:926-935.
  • Murphy LO, Abdel-Wahab YH, Wang QJ, Knezetic JA, Permnert J, Larsson J, Hollingsworth AM, Adrian TE. Receptors and ligands for autocrine growth pathways are up-regulated when pancreatic cancer cells are adapted to serum-free culture. Pancreas 2001;22:293-298.
  • Lynch HT, Brand RE, Hogg D, Deters CA, Fusaro RM, Lynch JF, Liu L, Knezetic J, Lassam NJ, Goggins M, Kern S. Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome. Cancer 2002;94:84-96.
  • Thomas WJ, Thomas DL, Knezetic JA, Adrian TE. The role of oxygen-derived free radicals and nitric oxide in cytokine-induced antiproliferation of pancreatic cancer cells. Pancreas 2002;24:161-168.
  • Tanko Q, Franklin B, Lynch H, Knezetic J. A hMLH1 genomic mutation and associated novel mRNA defects in a hereditary non-polyposis colorectal cancer family. Mutat Res 2002;503:37-42.
  • Staplin WR, Hodgson CP, Knezetic JA. Conserved, erythropoietin-responsive VL30 promoters isolated from erythroid progenitor cells. Blood Cells Mol Dis 2002;28:275-282.
  • Hart SJ, Knezetic JA, Petzel DH. Cloning and tissue distribution of two Na+/H+ exchangers from the Malpighian tubules of Aedes aegypti. Arch Insect Biochem Physiol 2002;51:121-135.
  • Staplin WR, Knezetic JA. BVL-1-like VL30 promoter sustains long-term expression in erythroid progenitor cells. Blood 2003;101:1798-1800.
  • Lynch HT, Taylor RJ, Lynch JF, Knezetic JA, Barrows A, Fodde R, Wijnen J, Wagner A. Multiple primary cancer, including transitional cell carcinoma of the upper uroepithelial tract in a multigeneration HNPCC family: molecular genetic, diagnostic, and management implications. Am J Gastroenterol 2003;98:664-670.
  • Cluck MW, Murphy LO, Olson J, Knezetic JA, Adrian TE. Amylin gene expression mediated by cAMP/PKA and transcription factors HNF-1 and NFY. Mol Cell Endocrinol 2003;210:63-75.
  • Rapuri PB, Gallagher JC, Knezetic JA, Kinyamu HK, Ryschon KL. Association between Vitamin D receptor polymorphisms and the rate of bone loss in elderly women—importance of adjusting for dietary and lifestyle factors. J Steroid Biochem Mol Biol 2004;89-90:503-506.
  • Rapuri PB, Gallagher JC, Knezetic JA, Haynatzka V. Estrogen receptor alpha gene polymorphisms are associated with changes in bone remodeling markers and treatment response to estrogen. Maturitas 2006 Mar 20;53(4):371-9.